A growing biotech company in Dublin is looking for a senior translational expert to lead IND-enabling activities. This role emphasizes scientific ownership and operational autonomy in a resource-efficient setting. The ideal candidate has a PhD, experiences with antibody modalities, and can manage projects through external partners. Competitive compensation includes equity and benefits, with Irish tax residency required for applicants. #J-18808-Ljbffr
My client is a growing venture-backed biotech is preparing for its first transition from advanced discovery into regulated development. Operating with a deliberately lean internal model and extensive use of external specialists, the organisation is hiring senior translational expertise to take scientific ownership of IND-enabling and early clinical readiness activities. This is an execution-led scientific role, not a scale up management position with a strong emphasis on the scientific ownership of IND-enabling and early clinical readiness activities from preclinical phase. This is a role for the discerning candidate who has a strong understanding of the pathway to clinic, someone who can creatively navigate, anticipate and respond to different internal and stakeholder needs and can operate independently to manage projects and processes end-to-end. I am looking for someone who is passionate about working not just on the cutting edge, but the bleeding edge of science, working in a true front-runner environment close to science an projects that are on the pathway to making a difference in patients lives. The Focus You will own the translational and non clinical strategy across one or more development programs, shaping pharmacology, PK/PD and toxicology plans that are regulator-ready and clinically grounded. Working closely with external CROs, consultants and toxicologists, you’ll act as the scientific bridge into CMC and early clinical planning, providing clear rationale to support development and investment decisions. About you This role is designed for someone who has personally led IND-enabling translational decisions and is comfortable operating with high autonomy in a resource-efficient environment. PhD-level scientific training Experience supporting regulated development of complex therapeutic programs (antibody modalities) Demonstrated ownership of non-clinical and/or translational packages used in regulatory interactions Comfortable working through external partners rather than large internal teams Irish tax residency required (non-negotiable) Competitive compensation with additional package components including equity/benefits #J-18808-Ljbffr
A pioneering biotech firm in Galway is seeking a Principal Scientist to lead their scientific direction in gene and cell therapies. The role involves overseeing experimental strategies and ensuring successful preclinical development while managing collaborations. Ideal candidates should hold a PhD in life sciences and have 5-7+ years of experience in biotech, particularly within translational research and regulatory environments. This position offers a competitive salary along with the opportunity to influence cutting-edge therapeutic advancements. #J-18808-Ljbffr
Principal Scientist Location: Ireland (on-site) Reports to: C‑Suite Summary I'm working with an exciting biotech who are looking for their first Head of Translational to lead their scientific direction and hands‑on lab execution for novel cell & gene therapies. Your role will be to drive programs from discovery into preclinical development and IND/CTA enabling stages. Work cross functionally with internal teams and external partners to advance multiple therapeutic candidates. This is not just an opportunity to work at the cutting edge but the bleeding edge of science, my client is looking for strong scientific experience and extensive experience in team leadership, management and building with future growth potential around 20 headcount. They are open to EU wide and international candidates and willing to offer support to bring the right person into the team. Responsibilities You will own the scientific strategy and experimental leadership across discovery programs Design and deliver preclinical studies focused on delivery, efficacy, safety, and MoA Develop and validate molecular and cellular potency/identity assays Lead cross‑functional project planning with CMC, translational and regulatory groups Manage collaborations with CRO/academia/industry partners Guide IP-relevant innovation and scientific documentation Mentor R&D team members and promote lab excellence and compliance Ensure data integrity, SOP adherence, equipment stewardship and safety standards Required Experience PhD in life sciences discipline (molecular/cell biology, gene therapy, immunology etc.) 5–7+ years post PhD experience in biotech or advanced biologics Proven Translational ability to progress therapeutics through discovery to IND enabling work Expertise in molecular & cellular engineering (RNA, gene delivery, transfection etc.) Experience with advanced cell & gene therapies highly advantageous Experience working with regulatory teams and frameworks Hands‑on analytical assay design and interpretation (e.g., qPCR, flow, ELISA, Western) Familiarity with upstream/downstream process development and scale‑up Understanding of GLP/GMP alignment and documentation for regulatory submissions Skilled in cross‑functional leadership and navigating fast‑moving biotech settings Preferred Respiratory or oncology models Experience supporting IND/CTA or IMPD enabling studies Personal Qualities Hands on, proactive scientific leadership Strong organization, analytical thinking, and attention to detail Resilient, collaborative and motivated by translational impact What’s Offered Lead cutting edge programs in gene delivery and regenerative medicine Visible role in a high growth biotech with major unmet need focus Competitive salary and performance‑linked compensation #J-18808-Ljbffr
